PREPARE Challenge: Proof of Principle Demonstration (Phase 3)

Advance algorithms and analytic approaches for early prediction of Alzheimer's disease and related dementias, with an emphasis on explainability of predictions. [Phase 3] #health

$222,500 in prizes
2 months left
11 joined

Overview

Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) are a set of brain disorders affecting more than 6 million Americans. Early intervention is crucial for successful disease modification, but detecting early signs of cognitive decline and AD/ADRD remains challenging. Current clinical methods often lack the sensitivity needed for early prediction, especially in underrepresented groups.

The objective of this challenge is to improve early prediction of Alzheimer's disease and related dementias (AD/ADRD) using acoustic biomarkers from voice recordings. Through this initiative, the National Institute on Aging (NIA) aims to improve accuracy across diverse populations and explore understudied factors that may indicate early AD/ADRD.


Submission deadline

July 15, 2025, 11:59 p.m. UTC


Prizes

Place Amount
1st $100,000
2nd $50,000
Runners-up (2) $25,000 each
Overall Prizes

Overall prizes will be awarded based on the overall prize evaluation criteria. Four overall prizes will be awarded: 1st Place, 2nd Place, and two Runners-up.

1st and 2nd Place winners will be invited to an in-person winner showcase. Additional participants may be invited to the event depending on capacity.

Number Awarded Amount
Up to 3 $7,500 each
Clean Code Bonus Prizes

Clean code bonus prizes will be awarded based on the clarity, reproducibility, and usability of each submitted codebase. See the problem description page for details.



Key events


How to compete

  1. Click the "Compete!" button in the sidebar to enroll in the competition. Note that you will need to be granted access. If you believe you should have access but do not, send an email to info@drivendata.org.
  2. Get familiar with the challenge task through the problem description, particularly the competition objectives.
  3. Create a submission according to the submission format.
  4. Click "Submit" in the sidebar, and upload your submission ZIP file. You can change your submission at any point before the final deadline by removing your previous submission, and then re-submitting a new file.
  5. Present your findings at the virtual pitch event.

Competition rules

The challenge rules are in place to promote fair competition and useful solutions. If you are ever unsure whether your solution meets the competition rules, ask the challenge organizers in the competition forum or send an email to info@drivendata.org. A few key rules are highlighted below. For more details, see the "Official rules" page.

External data usage

External data is permitted in this competition provided participants have all rights, licenses, and permissions to use it as contemplated in the Competition Rules. If you aren't sure whether a specific dataset is allowable, please reach out to the challenge organizers in the competition forum or send an email to info@drivendata.org

Participation in PREPARE Phase 2

Participants must compete as part of the same group that received an award in the PREPARE Challenge - Phase 2. Participants who received a Phase 2 award as part of a team cannot add new team members. If only a subset of the Phase 2 team members compete, the team is still eligible.

Data terms of use

Participants must follow all applicable terms of use for any data source, including using data for permitted purposes, limiting sharing to authorized parties, deleting data when no longer needed, and properly crediting the data providers.

Acoustic Track: Users of DementiaBank data must follow the DementiaBank ground rules. Users are not permitted to share competition data with any other person, must delete competition data after the competition concludes, and must properly credit DementiaBank as follows:

Lanzi, A. M., Saylor, A. K., Fromm, D., Liu, H., MacWhinney, B., & Cohen, M. L. (2023). DementiaBank: Theoretical rationale, protocol, and illustrative analyses. American Journal of Speech-Language Pathology, 32(2), 426-438.

Social Determinants Track: Users of MHAS data must agree to the MHAS terms of use. Users are not permitted to share competition data with any other person, must delete competition data after the competition concludes, and must properly credit MHAS as follows:

The MHAS (Mexican Health and Aging Study) is partly sponsored by the National Institutes of Health/National Institute on Aging (grant number NIH R01AG018016) in the United States and the Instituto Nacional de Estadística y Geografía (INEGI) in Mexico. Data files and documentation are public use and available at www.MHASweb.org.


Challenge sponsor

This challenge is sponsored by the National Institute on Aging (NIA), an institute of the National Institutes of Health (NIH)

US NIA Logo


with support from NASA

NTL Logo