PREPARE Challenge - Phase 2: Model Arena (Social Determinants Track)

Advance algorithms and analytic approaches for early prediction of Alzheimer's disease and related dementias based on social determinants of health, with an emphasis on explainability of predictions. [Model Arena - Social Determinants Track] #health

$130,000 in prizes
Completed dec 2024
440 joined

About the data

The data for ths Social Determinants Track of PREPARE Phase 2 comes from the Mexican Health and Aging Study (MHAS). The potential of these datasets for early prediction of Alzheimer's Disease and Alzheimer's Disease Related Dementias was identified by the 3rd place winners of Phase 1 of the PREPARE Challenge.

The Mexican Health and Aging Study (MHAS) is a nationally representative longitudinal survey of adults in Mexico 50 years and older. The survey collects comprehensive data on health, cognition, and socioeconomic factors related to aging. MHAS aims to enable cross-national comparisons of cognitive aging.

MHAS also includes multiple years of cognitive scores. These scores are calculated based on in-depth cognitive assessments administered in person. Cognitive assessments are useful for flagging AD/ADRD, but time-intensive and complex to perform, sometimes requiring more than 100 questions.

About social determinants of health (SDOH)

MHAS provides rich data for predicting and measuring cognitive decline. The information available in these datasets relates to several key Social Determinants of Health (SDOH), or nonmedical factors that affect health. SDOH describe the environments in which someone lives and spends their time, such as healthcare access and economic stability. SDOH affect a wide range of health and quality-of-life outcomes.

Illustration of the five key domains of social determinants of health: economic stability, education access and quality, health care access and quality, neighborhood and build environment, social and community context.

Five key domains of SDOH.
Image source: Healthy People 2030, U.S. Department of Health and Human Services, Office of Disease Prevention and Health Promotion.

Identifying key SDOH that are highly associated with AD/ADRD could potentially facilitate earlier and more accessible screening and intervention. SDOH data is often already collected and available in various formats, including medical records and population health surveys. Analyzing existing SDOH data may offer a less resource-intensive approach compared to administering specialized cognitive assessments, which are currently the standard for cognitive screening.

About the sponsor and challenge

The National Institute of Aging (NIA), one of the 27 Institutes and Centers of the National Institute of Health (NIH), leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. NIA is the primary Federal agency supporting and conducting Alzheimer's disease research.

This challenge is a Eureka Prize Competition, and is aligned with the objectives of the 42 U.S.C. 283q, which calls on NIH to support challenges in areas of biomedical science that could: 1) realize significant advancements and 2) improve health outcomes in human diseases and conditions, particularly with respect to human diseases and conditions for which public and private investment in research is disproportionately small relative to Federal Government expenditures on prevention and treatment activities, that are serious and represent a significant disease burden in the United States, or for which there is potential for significant return on investment to the United States.

Learn more